Circulating CCN6/WISP3 in type 2 diabetes mellitus patients and its correlation with insulin resistance and inflammation: statistical and machine learning analyses.

Journal: BMC medical informatics and decision making
PMID: 40050813

Abstract

INTRODUCTION: Cellular Communication Network Factor 6 (CCN6) is an adipokine whose production undergoes significant alterations in metabolic disorders. Given the well-established link between obesity-induced adipokine dysfunction and the development of insulin resistance and type 2 diabetes mellitus (T2DM), this study investigates the potential role of CCN6 as a biomarker for T2DM. The present study aimed to investigate the association between serum CCN6 levels and T2DM, as well as its risk factors, for the first time.

Authors

  • Reza Afrisham
    Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran. rafrisham@sina.tums.ac.ir.
  • Yasaman Jadidi
    Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
  • Nariman Moradi
    Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Seyed Mohammad Ayyoubzadeh
    Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
  • Reza Fadaei
    Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Omid Kiani Ghalesardi
    Department of Hematology and Blood Banking, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Vida Farrokhi
    Department of Hematology and Transfusion Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
  • Shaban Alizadeh
    Department of Hematology and Transfusion Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran. Alizadehs@sina.tums.ac.ir.

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