A deep-learning retinal aging biomarker for cognitive decline and incident dementia.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
PMID:

Abstract

INTRODUCTION: The utility of retinal photography-derived aging biomarkers for predicting cognitive decline remains under-explored.

Authors

  • Ming Ann Sim
    Department of Anaesthesia, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.
  • Yih Chung Tham
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. thamyc@nus.edu.sg.
  • Simon Nusinovici
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Ten Cheer Quek
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
  • Marco Yu
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Can Can Xue
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Miao Li Chee
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Qing Sheng Peng
    Centre for Innovation and Precision Eye Health, and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Eugene S J Tan
    National University Heart Centre, National University Hospital, Singapore, Singapore.
  • Siew Pang Chan
    Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore, 119228, Singapore.
  • Yuan Cai
    Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.
  • Eddie Jun Yi Chong
    Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore.
  • Boon Yeow Tan
    St Luke's Hospital, Singapore, Singapore.
  • Narayanaswamy Venketasubramanian
    Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.
  • Saima Hilal
    Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.
  • Mitchell K P Lai
    Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore.
  • Hyungwon Choi
    Cardiovascular Metabolic Disease Translational Research Program, National University of Singapore, Singapore, Singapore.
  • Arthur Mark Richards
    Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore.
  • Ching-Yu Cheng
    Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
  • Christopher L H Chen
    Memory Aging and Cognition Centre, Departments of Pharmacology and Psychological Medicine, National University of Singapore, Singapore, Singapore.