Investigation of cell development and tissue structure network based on natural Language processing of scRNA-seq data.

Journal: Journal of translational medicine
PMID: 40038714

Abstract

BACKGROUND: Single-cell multi-omics technologies, particularly single-cell RNA sequencing (scRNA-seq), have revolutionized our understanding of cellular heterogeneity and development by providing insights into gene expression at the single-cell level. Investigating the influence of genes on cellular behavior is crucial for elucidating cell fate determination and differentiation, cell development processes, and disease mechanisms.

Authors

  • Suwen Wei
    Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, Zhejiang, P. R. China.
  • Yuer Lu
    Wenzhou Institute and Wenzhou Key Laboratory of Biophysics, University of Chinese Academy of Sciences, Wenzhou, 325001, China.
  • Peng Wang
    Neuroengineering Laboratory, School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
  • Qichao Li
    Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, Zhejiang, P. R. China.
  • Jianwei Shuai
    Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen 361005, China; Wenzhou Institute, University of Chinese Academy of Sciences, and Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang 325001, China; National Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen 361102, China. Electronic address: jianweishuai@xmu.edu.cn.
  • Qi Zhao
  • Hai Lin
    Department of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Yuming Peng
    Department of General Practice, Central Hospital of Karamay, Xinjiang, 834000, P. R. China. 1584709828@qq.com.

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