The role of senescence-related genes in major depressive disorder: insights from machine learning and single cell analysis.

Journal: BMC psychiatry
PMID: 40033248

Abstract

BACKGROUND: Evidence indicates that patients with Major Depressive Disorder (MDD) exhibit a senescence phenotype or an increased susceptibility to premature senescence. However, the relationship between senescence-related genes (SRGs) and MDD remains underexplored.

Authors

  • Kun Lian
    Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, China.
  • Wei Yang
    Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China. Electronic address: 421063202@qq.com.
  • Jing Ye
    d Department of Digestive System Diseases, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang Province, China.
  • Yilan Chen
    Department of Psychiatry, The Second People's Hospital of Yuxi, No. 4, Xingyun Road, High-tech Development Zone, Yuxi, Yunnan, 653100, China.
  • Lei Zhang
    Division of Gastroenterology, Union Hospital, Tongji Medical College Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xiufeng Xu
    Nycrist Pharmatech Limited, 2/2D, A3, Science and Technology Park, 3009 Guanguang Rd, Guangming, Shenzhen, Guangdong 518107, China.

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