An integrated machine learning model of transcriptomic genes in multi-center chronic obstructive pulmonary disease reveals the causal role of TIMP4 in airway epithelial cell.

Journal: Respiratory research
PMID: 40269868

Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome, resulting in inconsistent findings across studies. Identifying a core set of genes consistently involved in COPD pathogenesis, independent of patient variability, is essential.

Authors

  • Erkang Yi
    Guangzhou National Laboratory, No.9 Xing Dao Huan Bei Road, Guangzhou International BioIsland, Guangzhou, 510005, Guangdong, China.
  • Haiqing Li
    Department of Control Science and Engineering, Tongji University, Shanghai, 201804, China.
  • Yu Liu
    Research Center of Information Technology, Beijing Academy of Agriculture and Forestry Science, Beijing, China.
  • Qingyang Li
    School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ, USA.
  • Chengshu Xie
    Guangzhou National Laboratory, No.9 Xing Dao Huan Bei Road, Guangzhou International BioIsland, Guangzhou, 510005, Guangdong, China.
  • Ruining Sun
    State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, No.195 Dong Feng Xi Road, Guangzhou, 510182, Guangdong, China.
  • Fan Wu
    Department of Product Design, Dalian Polytechnic University, Dalian 116034, China.
  • Zhishan Deng
    State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, No.195 Dong Feng Xi Road, Guangzhou, 510182, Guangdong, China.
  • Kunning Zhou
    State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, No.195 Dong Feng Xi Road, Guangzhou, 510182, Guangdong, China.
  • Hairong Wang
    College of Computing, Georgia Institute of Technology, Atlanta, GA, USA.
  • Xinru Ran
    GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Yumin Zhou
    State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, No.195 Dong Feng Xi Road, Guangzhou, 510182, Guangdong, China. zhouyumin410@126.com.
  • Pixin Ran
    State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, No.195 Dong Feng Xi Road, Guangzhou, 510182, Guangdong, China. pxran@gzhmu.edu.cn.

Keywords

External Resources

Popular Topics
Recent Journals