AIMC Topic: Mice, Inbred C57BL

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Integrating artificial intelligence and optogenetics for Parkinson's disease diagnosis and therapeutics in male mice.

Nature communications Aug 21, 2025
Parkinson's disease (PD), a progressive neurodegenerative disorder, presents complex motor symptoms and lacks effective disease-modifying treatments. Here we show that integrating artificial intelligence (AI) with optogenetic intervention, termed opt...
Behavior, Animal Mice, Transgenic Optogenetics Animals Humans Male Disease Models, Animal Artificial Intelligence Mice Mice, Inbred C57BL Parkinson Disease Gait
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Balancing ethics and statistics: machine learning facilitates highly accurate classification of mice according to their trait anxiety with reduced sample sizes.

Translational psychiatry Aug 21, 2025
Understanding how individual differences influence vulnerability to disease and responses to pharmacological treatments represents one of the main challenges in behavioral neuroscience. Nevertheless, inter-individual variability and sex-specific patt...
Sample Size Anxiety Machine Learning Supervised Machine Learning Mice Behavior, Animal Female Disease Models, Animal Endophenotypes Animals Mice, Inbred C57BL Male
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Comprehensive multi-omics analysis reveals the core role of glycerophospholipid metabolism in the influence of short-chain fatty acids on the development of sepsis.

Scientific reports Aug 9, 2025
Sepsis is a systemic inflammatory response syndrome caused by infection, which has a high morbidity and mortality. Short-chain fatty acids (SCFAs) have been proved to improve the outcome of sepsis by regulating immunity and metabolism, but its specif...
Mice, Inbred C57BL Metabolomics Mendelian Randomization Analysis Fatty Acids, Volatile Mice Multiomics Disease Models, Animal Glycerophospholipids Humans Animals Male Gene Expression Profiling Transcriptome Sepsis
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Subsecond Analysis of Locomotor Activity in Parkinsonian Mice.

eNeuro Aug 5, 2025
The degeneration of midbrain dopamine (DA) neurons disrupts the neural control of natural behavior, such as walking, posture, and gait in Parkinson's disease. While some aspects of motor symptoms can be managed by DA replacement therapies, others res...
Locomotion Mice Antiparkinson Agents Levodopa Disease Models, Animal Dopaminergic Neurons Mice, Inbred C57BL Parkinsonian Disorders Animals Male
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Candesartan Mitigates Perioperative Neurocognitive Disorders by Modulating Hypertension-Linked Neuroinflammatory Factor.

Neurochemical research Jul 29, 2025
Perioperative neurocognitive disorders (PND) are linked to neuroinflammation, a key factor in hypertension, but their causal relationship is underexplored. This study aims to investigate whether hypertension is a risk factor for PND, identify related...
Thrombospondin 1 Tetrazoles Benzimidazoles Angiotensin II Type 1 Receptor Blockers Neurocognitive Disorders Mice, Inbred C57BL Neuroinflammatory Diseases Biphenyl Compounds Animals Male Mice Hypertension
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An integrative assay for measuring social aversion and motivation in freely behaving mice.

Cell reports methods Jul 17, 2025
Social aversion is a key feature of numerous mental health disorders, yet we lack adequate behavioral tools to interrogate social aversion in model systems. Here, we developed a behavioral task-selective access to unrestricted social interaction (SAU...
Mice Mice, Inbred C57BL Social Isolation Motivation Animals Male Social Interaction Avoidance Learning Behavior, Animal Fear Social Behavior
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Shared pathogenic mechanisms linking obesity and idiopathic pulmonary fibrosis revealed by bioinformatics and in vivo validation.

Scientific reports Jul 17, 2025
Previous studies have suggested a potential correlation between obesity and idiopathic pulmonary fibrosis (IPF). This study aimed to elucidate pathogenic pathways connecting obesity and IPF and identify diagnostic biomarkers for obesity-related pulmo...
Gene Regulatory Networks Mice Computational Biology Disease Models, Animal Idiopathic Pulmonary Fibrosis Mice, Inbred C57BL Obesity Male Molecular Docking Simulation Gene Expression Profiling Protein Interaction Maps Humans Machine Learning Animals Diet, High-Fat
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DeepEthoProfile-Rapid Behavior Recognition in Long-Term Recorded Home-Cage Mice.

eNeuro Jul 15, 2025
Animal behavior is crucial for understanding both normal brain function and dysfunction. To facilitate behavior analysis of mice within their home environments, we developed DeepEthoProfile, an open-source software powered by a deep convolutional neu...
Neural Networks, Computer Software Mice, Inbred C57BL Video Recording Housing, Animal Behavior, Animal Animals Male Mice
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CalTrig: A GUI-Based Machine Learning Approach for Decoding Neuronal Calcium Transients in Freely Moving Rodents.

eNeuro Jul 15, 2025
Advances in in vivo Ca imaging using miniature microscopes have enabled researchers to study single-neuron activity in freely moving animals. Tools such as Minian and CalmAn have been developed to convert Ca visual signals to numerical data, collecti...
Calcium User-Computer Interface Machine Learning Calcium Signaling Mice Animals Mice, Inbred C57BL Male Neurons
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Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity.

Nature communications Jul 14, 2025
Innovative identification technologies for hematopoietic stem cells (HSCs) have expanded the scope of stem cell biology. Clinically, the functional quality of HSCs critically influences the safety and therapeutic efficacy of stem cell therapies. Howe...
Hematopoietic Stem Cells Humans Quantitative Phase Imaging Mice Machine Learning Mice, Inbred C57BL Algorithms Kinetics Animals Single-Cell Analysis
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