Machine learning technique-based four-autoantibody test for early detection of esophageal squamous cell carcinoma: a multicenter, retrospective study with a nested case-control study.

Journal: BMC medicine
PMID: 40264204

Abstract

BACKGROUND: Autoantibodies represent promising diagnostic blood-based biomarkers that may be generated prior to the first clinically detectable signs of cancers. In present study, we aimed to identify a novel optimized autoantibody panel with high diagnostic accuracy for clinical and preclinical esophageal squamous cell carcinoma (ESCC) using machine learning (ML) algorithms.

Authors

  • Yi-Wei Xu
    Department of Clinical Laboratory Medicine, Esophageal Cancer Prevention and Control Research Center, Chaoshan Branch of State Key Laboratory for Esophageal Cancer Prevention and Treatment, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China. yiwei512@126.com.
  • Yu-Hui Peng
    Department of Clinical Laboratory Medicine, Esophageal Cancer Prevention and Control Research Center, Chaoshan Branch of State Key Laboratory for Esophageal Cancer Prevention and Treatment, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China.
  • Can-Tong Liu
    Department of Clinical Laboratory Medicine, Esophageal Cancer Prevention and Control Research Center, Chaoshan Branch of State Key Laboratory for Esophageal Cancer Prevention and Treatment, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China.
  • Hao Chen
    The First School of Medicine, Wenzhou Medical University, Wenzhou, China.
  • Ling-Yu Chu
    Department of Clinical Laboratory Medicine, Esophageal Cancer Prevention and Control Research Center, Chaoshan Branch of State Key Laboratory for Esophageal Cancer Prevention and Treatment, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China.
  • Hai-Lu Chen
    Department of Surgical Oncology, Shantou Central Hospital, Shantou, 515031, China.
  • Zhi-Yong Wu
    Clinical Research Center & Breast Disease Diagnosis and Treatment Center, Shantou Central Hospital, Shantou, China.
  • Wen-Qiang Wei
    Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. weiwq@cicams.ac.cn.
  • Li-Yan Xu
    Institute of Oncological Pathology, Shantou University Medical College, Shantou, 515041, China. lyxu@stu.edu.cn.
  • Fang-Cai Wu
    Department of Radiation Oncology, Esophageal Cancer Prevention and Control Research Center, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China. 280550109@qq.com.
  • En-Min Li
    Esophageal Cancer Prevention and Control Research Center, Chaoshan Branch of State Key Laboratory for Esophageal Cancer Prevention and Treatment, Cancer Hospital of Shantou University Medical College, Shantou, 515041, China. nmli@stu.edu.cn.

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