Large-scale bulk and single-cell RNA sequencing combined with machine learning reveals glioblastoma-associated neutrophil heterogeneity and establishes a VEGFA neutrophil prognostic model.

Journal: Biology direct
PMID:

Abstract

BACKGROUND: Neutrophils play a key role in the tumor microenvironment (TME); however, their functions in glioblastoma (GBM) are overlooked and insufficiently studied. A detailed analysis of GBM-associated neutrophil (GBMAN) subpopulations may offer new insights and opportunities for GBM immunotherapy.

Authors

  • Yufan Yang
    Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Ziyuan Liu
    Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.
  • Zhongliang Wang
    Engineering Research Center of Molecular, Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
  • Xiang Fu
    College of Mining Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China.
  • Zhiyong Li
    School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
  • Jianlong Li
    Department of Physical Education, Suzhou University of Science and Technology, Suzhou, 215009, Jiangsu, China. ljl@usts.edu.cn.
  • Zhongyuan Xu
    Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. nflcyljd@smu.edu.cn.
  • Bohong Cen
    Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. cenbohong22@i.smu.edu.cn.