Machine learning in prediction of epidermal growth factor receptor status in non-small cell lung cancer brain metastases: a systematic review and meta-analysis.

Journal: BMC cancer
PMID: 40312289

Abstract

BACKGROUND: Epidermal growth factor receptor (EGFR) mutations are present in 10-60% of all non-small cell lung cancer (NSCLC) patients and are associated with dismal prognosis. Lung cancer brain metastases (LCBM) are a common complication of lung cancer. Predictions of EGFR can help physicians in decision-making and, through optimizing treatment strategies, can result in more favorable outcomes. This systematic review and meta-analysis evaluated the predictive performance of machine learning (ML)-based models in EGFR status in NSCLC patients with brain metastasis.

Authors

  • Bardia Hajikarimloo
    Skull Base Research Center, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Ibrahim Mohammadzadeh
    Skull Base Research Center, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Ibrahim.mdz7777@gmail.com.
  • Salem M Tos
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA.
  • Mohammad Amin Habibi
    Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Rana Hashemi
    Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences, Tehran, Iran.
  • Ehsan Bahrami Hezaveh
    Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Dorsa Najari
    Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Arman Hasanzade
    Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mehdi Hooshmand
    Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Sara Bana
    Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

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