Deep Learning Model of Primary Tumor and Metastatic Cervical Lymph Nodes From CT for Outcome Predictions in Oropharyngeal Cancer.

Journal: JAMA network open
PMID:

Abstract

IMPORTANCE: Primary tumor (PT) and metastatic cervical lymph node (LN) characteristics are highly associated with oropharyngeal squamous cell carcinoma (OPSCC) prognosis. Currently, there is a lack of studies to combine imaging characteristics of both regions for predictions of p16+ OPSCC outcomes.

Authors

  • Bolin Song
    Digital Science, AbbVie, North Chicago, IL 60064, USA.
  • Amaury Leroy
    Therapanacea, Paris, France.
  • Kailin Yang
    Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio, USA.
  • Sirvan Khalighi
    Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.
  • Krunal Pandav
    Department of Urology, Icahn School of Medicine at Mount Sinai Hospital, New York City, New York, USA.
  • Tanmoy Dam
    Department of Biomedical Engineering, Emory University, GA, USA.
  • Jonathan Lee
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
  • Sarah Stock
    Diagnostics Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Xiao T Li
    Department of Radiology and Imaging Sciences, Emory University Hospital, Atlanta, GA, USA.
  • Jay Sonuga
    Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.
  • Pingfu Fu
    Department of Biomedical Engineering, Case Western Reserve University School of Engineering, 2071 Martin Luther King Dr, Cleveland, OH 44106-7207 (M. Khorrami, K.B., A.M.); Departments of Internal Medicine (M. Khunger) and Solid Tumor Oncology (A.Z., P.P.), Cleveland Clinic, Cleveland, Ohio; Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio (P.F.); Department of Hematology and Oncology, New York University, New York, NY (V.V.); Louis Stokes Cleveland Veterans Administration Medical Center, Cleveland, Ohio (A.M.).
  • Shlomo Koyfman
    Cleveland Clinic Foundation, Cleveland, Ohio, USA.
  • Nabil F Saba
    Department of Hematology and Medical Oncology, The Winship Cancer Institute, Emory University, Atlanta, GA, USA.
  • Mihir R Patel
    Department of Otolaryngology, Winship Cancer Institute, Atlanta, GA, USA.
  • Anant Madabhushi
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.