Integrated machine learning survival framework develops a prognostic model based on macrophage-related genes and programmed cell death signatures in a multi-sample Kidney renal clear cell carcinoma.

Journal: Cell biology and toxicology
Published Date:

Abstract

BACKGROUND: Macrophages are closely associated with the progression of Kidney renal clear cell carcinoma (KIRC) and can influence programmed cell death (PCD) of tumour cells. To identify prognostic biomarkers for KIRC, it is essential to investigate the association between macrophage-related genes and PCD characteristics.

Authors

  • Xuefei Liu
    School of Mechanical Engineering, Anhui University of Technology, Ma'anshan 240302, China.
  • Min Deng
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China.
  • Xing Luo
    College of Mechanical and Control Engineering, Guilin University of Technology, Guilin, Guangxi 541004, China.
  • Tingting Li
    Key Laboratory of Biotechnology and Bioresources Utilization (Dalian Minzu University), Ministry of Education, Dalian, China.
  • Yanan Ge
    Department of Oncology, Northern Theater Command General Hospital, Shenyang, 110016, Liaoning, China.
  • Jianong Li
    Department of Oncology, Northern Theater Command General Hospital, Shenyang, 110016, Liaoning, China.
  • Jiang Zhao
    Yunan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
  • Limin Yang
    State Key Laboratory of Mechanical System and Vibration, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.