Dual-mode nanosensor for sensitive detection of methotrexate based on fluorescence technology and deep learning algorithms.

Journal: Analytica chimica acta
Published Date: May 14, 2025

Abstract

BACKGROUND: Methotrexate (MTX) in the body can result in severe, potentially life-threatening side effects. As a result, it is imperative to establish a dependable, precise, and specific method for detecting MTX. However, conventional sensors often suffer from limitations such as low sensitivity, prolonged response times, and insufficient accuracy.

Authors

  • Chenyue Kang
    School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China.
  • Yueying Li
    College of Information Engineering, Xinyang Agriculture and Forestry University, Xinyang 464000, China.
  • Yan Zhang
    Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China.
  • Ying Zhou
    Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
  • Caihong Zhang
    Department of Health, Disease Control and Prevention of Yulin Center, Yulin, 719000 Shaanxi, China.
  • Shaomin Shuang
    College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, PR China. Electronic address: smshuang@sxu.edu.cn.
  • Guomei Zhang
    School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, China. Electronic address: gmzhang@sxu.edu.cn.

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