The simultaneous determination of the expression levels of multiple inflammation-associated cytokines in blood holds great promise for the early screening of cancer including colorectal cancer (CRC). Herein, an antibody microarray-based sandwich meta...
Investigations on epithelial-mesenchymal transition (EMT) events occurring on circulating tumor cells (CTCs) are poised to significantly advance nanoliquid biopsy methodologies. This study presented a colorimetric multiplex lateral flow immunoassay s...
The escalating global crisis of multidrug-resistant (MDR) bacteria demands innovative strategies that bypass conventional antibiotic limitations. This study introduced a multifunctional Au@CuSe core-shell nanoplatform integrating artificial intellige...
Urinary glucose, creatinine, and uric acid are vital biomarkers for diabetes and kidney disease management. However, multiplex point-of-care detection faces challenges due to insufficient sensitivity in complex urine matrices and signal cross-talk fr...
Proceedings of the National Academy of Sciences of the United States of America
Nov 24, 2025
Cryoelectron tomography (cryo-ET) enables three-dimensional visualization of molecular structures within tissue and intact cells, providing a powerful tool for studying the spatial organization of biological components at nanometer resolution. Realiz...
Signature-based protein detection coupled with machine learning algorithms has revolutionized traditional sensing methods, providing rapid, inexpensive, and selectivity-driven detection without the use of specialized equipment. This strategy leverage...
Neurofilament light chain (NfL), a cytoskeletal protein released during neuronal injury, is a promising biomarker, with elevated levels consistently associated with disease severity and progression in multiple neurological conditions, including Alzhe...
Shiga toxins-producing (STEC) are zoonotic pathogens causing severe diseases such as hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). Infections caused by STEC represent a public health concern due to the severity of the possible outcom...
Diabetes mellitus (DM), a prevalent metabolic disorder, poses significant diagnostic and therapeutic challenges, especially, in the early stage diagnosis of diabetes related complications. Accurate early stage diagnosis of diabetes and its complicati...
The evolution of biosensors demands synergistic improvements in signal transduction and data processing. We present a universal biosensing platform that combines dual-mode signal responses from silver-modulated gold nanorods (AuNRs) and gold-silver n...
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