AIMC Topic: Methotrexate
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Prediction of High-Dose Methotrexate Blood Concentration in Osteosarcoma Patients Using Machine Learning.
Drug design, development and therapy
May 3, 2025
INTRODUCTION: High-dose methotrexate is a typical chemotherapy that is widely used in the treatment of osteosarcoma. However, the unique dose-response relationship of methotrexate makes its treatment window relatively narrow, and its clinical use is ...
Prediction of early recurrence in primary central nervous system lymphoma based on multimodal MRI-based radiomics: A preliminary study.
European journal of radiology
Apr 18, 2025
OBJECTIVES: To evaluate the role of multimodal magnetic resonance imaging radiomics features in predicting early recurrence of primary central nervous system lymphoma (PCNSL) and to investigate their correlation with patient prognosis.
Common genetic variants do not impact clinical prediction of methotrexate treatment outcomes in early rheumatoid arthritis.
Journal of internal medicine
Apr 6, 2025
BACKGROUND: Methotrexate (MTX) is the mainstay initial treatment of rheumatoid arthritis (RA), but individual response varies and remains difficult to predict. The role of genetics remains unclear, but studies suggest its importance.
Binding and sensing diverse small molecules using shape-complementary pseudocycles.
Science (New York, N.Y.)
Jul 18, 2024
We describe an approach for designing high-affinity small molecule-binding proteins poised for downstream sensing. We use deep learning-generated pseudocycles with repeating structural units surrounding central binding pockets with widely varying sha...
Using ChatGPT-Like Solutions to Bridge the Communication Gap Between Patients With Rheumatoid Arthritis and Health Care Professionals.
JMIR medical education
Feb 27, 2024
The communication gap between patients and health care professionals has led to increased disputes and resource waste in the medical domain. The development of artificial intelligence and other technologies brings new possibilities to solve this prob...
Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial.
The Lancet. Rheumatology
Dec 12, 2023
BACKGROUND: Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv...
Assessing the accuracy and completeness of artificial intelligence language models in providing information on methotrexate use.
Rheumatology international
Sep 25, 2023
We aimed to assess Large Language Models (LLMs)-ChatGPT 3.5-4, BARD, and Bing-in their accuracy and completeness when answering Methotrexate (MTX) related questions for treating rheumatoid arthritis. We employed 23 questions from an earlier study rel...
Multiple switching between the biosimilar adalimumab PF-06410293 and reference adalimumab in patients with active rheumatoid arthritis: a phase 3, open-label, randomised, parallel-group study.
The Lancet. Rheumatology
Aug 21, 2023
BACKGROUND: An adalimumab biosimilar with an interchangeability designation could increase access to effective treatment for more patients. We aimed to assess the interchangeability of adalimumab biosimilar PF-06410293 (adalimumab-afzb) and reference...
Risk prediction for delayed clearance of high-dose methotrexate in pediatric hematological malignancies by machine learning.
International journal of hematology
Jun 25, 2021
This study aimed to establish a predictive model to identify children with hematologic malignancy at high risk for delayed clearance of high-dose methotrexate (HD-MTX) based on machine learning. A total of 205 patients were recruited. Five variables ...
The feasibility of developing biomarkers from peripheral blood mononuclear cell RNAseq data in children with juvenile idiopathic arthritis using machine learning approaches.
Arthritis research & therapy
Nov 9, 2019
BACKGROUND: The response to treatment for juvenile idiopathic arthritis (JIA) can be staged using clinical features. However, objective laboratory biomarkers of remission are still lacking. In this study, we used machine learning to predict JIA activ...
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