Artificial intelligence and omics-based autoantibody profiling in dementia.

Journal: Frontiers in immunology
Published Date: May 8, 2025

Abstract

INTRODUCTION: Dementia is a neurodegenerative syndrome marked by the accumulation of disease-specific proteins and immune dysregulation, including autoimmune mechanisms involving autoantibodies. Current diagnostic methods are often invasive, time-consuming, or costly.

Authors

  • Kazuki M Matsuda
    Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Yumi Umeda-Kameyama
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kazuhiro Iwadoh
    Department of Nephrology, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, 162-8666, Japan.
  • Masashi Miyawaki
    Department of Geriatric Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Mitsutaka Yakabe
    Department of Geriatric Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Masaki Ishii
    Department of Geriatric Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Sumito Ogawa
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Masahiro Akishita
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Shinichi Sato
    Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Ayumi Yoshizaki
    Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: ayuyoshi@me.com.

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