Automatic transformer-based grading of multiple retinal inflammatory signs in uveitis on fluorescein angiography.

Journal: Computers in biology and medicine
Published Date:

Abstract

BACKGROUND: Grading fluorescein angiography (FA) for uveitis is complex, often leading to the oversight of retinal inflammation in clinical studies. This study aims to develop an automated method for grading retinal inflammation.

Authors

  • Victor Amiot
    Department of Ophthalmology, University of Lausanne, Fondation Asile des Aveugles, Jules Gonin Eye Hospital, Lausanne, Switzerland; Platform for Research in Ocular Imaging, Fondation Asile des Aveugles, Jules Gonin Eye Hospital, Lausanne, Switzerland.
  • Oscar Jimenez-Del-Toro
    University of Applied Sciences Western Switzerland (HES-SO) Valais, Sierre, Switzerland.
  • Yan Guex-Crosier
    Department of Ophthalmology, University of Lausanne, Fondation Asile des Aveugles, Jules Gonin Eye Hospital, Lausanne, Switzerland; Ocular Immune-infectiology Unit Jules-Gonin Eye Hospital, FAA, University of Lausanne, Switzerland.
  • Muriel Ott
    Department of Ophthalmology, University of Lausanne, Fondation Asile des Aveugles, Jules Gonin Eye Hospital, Lausanne, Switzerland; Ocular Immune-infectiology Unit Jules-Gonin Eye Hospital, FAA, University of Lausanne, Switzerland.
  • Teodora-Elena Bogaciu
    Grenoble Alpes University, Grenoble, France; Department of Ophthalmology, Grenoble Alpes University Hospital, Grenoble, France.
  • Shalini Banerjee
    Department of Ophthalmology, Cantonal Hospital Lucerne, Lucerne, Switzerland; Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland.
  • Jeremy Howell
    Department of Ophthalmology, Cantonal Hospital Lucerne, Lucerne, Switzerland; Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland.
  • Christoph Amstutz
    Department of Ophthalmology, Cantonal Hospital Lucerne, Lucerne, Switzerland; Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland.
  • Christophe Chiquet
    From the Singapore National Eye Center (D.M., D.T., S.S., C.-Y.C., T.Y.W.), Singapore Eye Research Institute (D.M., R.P.N., D.T., C.V., S.S., C.-Y.C., T.Y.W.), Duke-NUS Medical School (D.M., R.P.N., D.T., S.S., C.-Y.C., T.Y.W.), Institute of High Performance Computing, Agency for Science, Technology, and Research (J.Z., X.X., Y.L.), and Yong Loo Lin School of Medicine, National University of Singapore (S.S., T.Y.W.) - all in Singapore; Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran (M.A.F.); the Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, and the Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra, Portugal (P.F.); the Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (K.V.); the Eye Center, Medical Center, University of Freiburg, Freiburg (W.A.L.), and the Department of Ophthalmology, Ruprecht Karl University of Heidelberg, Mannheim (J.B.J.) - both in Germany; IRCCS Istituto delle Scienze Neurologiche di Bologna, Unità Operativa Complessa Clinica Neurologica, and Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy (C.L.M.); the Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong (C.Y.C.), and Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou (H.Y.) - both in China; the Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Glostrup, Denmark (S.H.); the Department of Ophthalmology, University Hospital of Grenoble-Alpes, and Grenoble-Alpes University, HP2 Laboratory, INSERM Unité 1042, Grenoble (C.C.), Service d'Ophtalmologie, Unité Rétine-Uvéites-Neuro-Ophtalmologie, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Bordeaux (M.-B.R.), the Department of Ophthalmology, Lille Catholic Hospital, Lille Catholic University, and INSERM Unité 1171, Lille (T.T.H.C.), the Department of Ophthalmology, University Hospital Angers, Angers (P.G.), and Rothschild Foundation Hospital, Paris (C.C.-V.) - all in France; the Department of Clinical Neurosciences, Geneva University Hospital, Geneva (N.S.); the Department of Neurology, SUNY Upstate Medical University, Syracuse, NY (L.J.M.); the American Eye Center, Mandaluyong City, Philippines (R.K.); Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, University College London, London (P.Y.-W.-M.), and Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge University Hospitals, and Cambridge Centre for Brain Repair and Medical Research Council Mitochondrial Biology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge (P.Y.-W.-M.) - all in the United Kingdom; the Save Sight Institute, Faculty of Health and Medicine, University of Sydney, Sydney (C.L.F.); the Department of Ophthalmology and Neurology, Mayo Clinic, Rochester, MN (J.J.C.); the Department of Neuro-ophthalmology, Sankara Nethralaya, Medical Research Foundation, Chennai, India (S.A.); the Departments of Ophthalmology, Neurology, and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore (N.R.M.); and the Departments of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta (N.J.N., V.B.).
  • Ciara Bergin
    Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.
  • Ilenia Meloni
    Department of Ophthalmology, University of Lausanne, Fondation Asile des Aveugles, Jules Gonin Eye Hospital, Lausanne, Switzerland; Platform for Research in Ocular Imaging, Fondation Asile des Aveugles, Jules Gonin Eye Hospital, Lausanne, Switzerland.
  • Mattia Tomasoni
    Department of Public Health and Caring Sciences, Uppsala University, Box 564, Husargatan 3, SE - 75122, Uppsala, Sweden.
  • Florence Hoogewoud
    Department of Ophthalmology, University of Lausanne, Fondation Asile des Aveugles, Jules Gonin Eye Hospital, Lausanne, Switzerland; Ocular Immune-infectiology Unit Jules-Gonin Eye Hospital, FAA, University of Lausanne, Switzerland.
  • André Anjos
    Idiap Research Institute, Martigny, Switzerland.