Altered aminoacid and lipid metabolism in a rat orofacial inflammation model determined by omics approach: potential role in trigeminal sensitisation.

Journal: The journal of headache and pain
PMID: 40340645

Abstract

BACKGROUND: Trigeminal activation and sensitisation involved in chronic inflammatory orofacial pain share several similarities with headaches, including migraine. Therefore, understanding the pathophysiological mechanisms is important to determine novel therapies, in which animal models are crucial. Here we aimed to identify key mediators, mechanisms and networks using unbiased multi-omic approaches in a rat orofacial inflammatory pain model.

Authors

  • Krisztina Takács-Lovász
    Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
  • Timea Aczél
    Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
  • Violetta Mohos
    Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
  • Máté Harmath
    Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
  • Jennet Pirkuliyeva
    Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
  • Gellért Karvaly
    Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary.
  • Róbert Farkas
    Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary.
  • Michal Ciborowski
    Metabolomics and Proteomics Laboratory, Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
  • Joanna Godzien
    Metabolomics and Proteomics Laboratory, Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
  • Kata Bölcskei
    Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
  • József Kun
    Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
  • Zsuzsanna Helyes
    Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary. zsuzsanna.helyes@aok.pte.hu.

Keywords

External Resources

Popular Topics
Recent Journals