Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study.

Journal: Frontiers in immunology
Published Date: Jan 1, 2025

Abstract

AIM OF THE STUDY: To establish a cross-tissue bioinformatics model for identifying conserved key genes and immune infiltration mechanisms in ischemia-reperfusion injury (IRI) with experimental validation in limb IRI, including pharmacological targeting of the WNT5A/PLC pathway.

Authors

  • Qiyun Shi
    Medical Center of Cervical and Lumbar Pain (Tui Na Therapy), Luoyang Orthopedic-Traumatological Hospital Of Henan Province (Henan Provincial Orthopedic Hospital), Luoyang, China.
  • Taotao Tian
    Medical Center of Cervical and Lumbar Pain (Tui Na Therapy), Luoyang Orthopedic-Traumatological Hospital Of Henan Province (Henan Provincial Orthopedic Hospital), Luoyang, China.
  • Yanfeng Li
    School of Electronic and Information Engineering, Beijing Jiaotong University, Shangyuan Village No 3 in Haidian, Beijing, China.

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