BACKGROUND: In the context of liver resection and transplantation, hepatic ischemia-reperfusion injury (hepatic IRI) remains a significant clinical challenge, profoundly impacting both postoperative short- and long-term recovery. A novel cell death p...
BACKGROUND: Hepatic ischemia-reperfusion injury (HIRI) represents the leading cause of postoperative liver dysfunction and failure. Ammonia-induced cell death (ACD), defined by lysosomal and mitochondrial disruption due to intracellular ammonia accum...
This study presents a supervised machine learning approach using a Random Forest classifier to detect ischemia-reperfusion injury (IRI) in kidney tissue based on intravital two-photon microscopy data. A rodent model of unilateral renal IRI was used, ...
BACKGROUND: Protein lactylation has been implicated in stress-responsive cellular mechanisms, yet its role in lung transplantation-associated ischemia-reperfusion injury (IRI) remains undefined.
Acute kidney injury (AKI) is a common and increases risk of chronic kidney disease (CKD). While mitochondrial dysfunction drives maladaptive repair, the role of glycolysis in renal recovery remains unclear. Here, we integrated single-cell transcripto...
Acute kidney injury (AKI) affects more than 20% of hospitalized patients and is a significant contributor to morbidity and mortality, primarily due to ischemia-reperfusion injury (IRI), which is one of the leading causes of AKI. IRI not only exacerba...
Kidney disease is a dangerous disease that affects human health and causes various defects. Renal microbiological changes can be monitored using optical coherence tomography (OCT) images to identify the nature of the disease based on behavior during ...
UNLABELLED: Although the link between ischemia-reperfusion injury (IRI) and T cell-mediated rejection (TCMR) in kidney transplantation (KT) is well known, the mechanism remains unclear. We investigated essential genes and biological processes involve...
BACKGROUND: Ex vivo lung perfusion (EVLP) is a critical strategy to rehabilitate marginal donor lungs, thereby increasing lung transplantation (LTx) rates. Ischemia-reperfusion (I/R) injury inevitably occurs during LTx. Exploring the common mechanism...
BACKGROUND: Renal cold ischemia-reperfusion injury (CIRI), a pathological process during kidney transplantation, may result in delayed graft function and negatively impact graft survival and function. There is a lack of an accurate and non-invasive t...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.