Antifungal activity and mechanism of novel peptide antimicrobial peptide (GmAMP) against fluconazole-resistant .

Journal: PeerJ
Published Date: May 20, 2025

Abstract

BACKGROUND: There is a pressing need to create innovative alternative treatment approaches considering the overuse of antifungal drugs causes the number of clinically isolated fluconazole-resistant species to increase. antimicrobial peptide (GmAMP) is a novel peptide screened by us using artificial intelligence modeling techniques, and pre-tests showed its strong antimicrobial activity against clinically fluconazole-resistant .

Authors

  • Ruxia Cai
    School of Basic Medical Sciences, Guizhou Key Laboratory of Microbial and Infectious Disease Prevention & Control, Guizhou Medical University, Guiyang, Guizhou, China.
  • Na Zhao
    Department of Gynecology, Peking University First Hospital Ningxia Women and Children's Hospital, Yinchuan, Ningxia, China.
  • Chaoqin Sun
    School of Basic Medical Sciences, Guizhou Key Laboratory of Microbial and Infectious Disease Prevention & Control, Guizhou Medical University, Guiyang, Guizhou, China.
  • Mingjiao Huang
    School of Basic Medical Sciences, Guizhou Key Laboratory of Microbial and Infectious Disease Prevention & Control, Guizhou Medical University, Guiyang, Guizhou, China.
  • Zhenlong Jiao
    School of Basic Medical Sciences, Guizhou Key Laboratory of Microbial and Infectious Disease Prevention & Control, Guizhou Medical University, Guiyang, Guizhou, China.
  • Jian Peng
    Department of Computer Science, University of Illinois Urbana-Champaign, Urbana, IL, USA.
  • Jin Zhang
    Department of Otolaryngology, The Second People's Hospital of Yibin, Yibin, Sichuan, China.
  • Guo Guo
    School of Basic Medical Sciences, Guizhou Key Laboratory of Microbial and Infectious Disease Prevention & Control, Guizhou Medical University, Guiyang, Guizhou, China.

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