AIMC Topic: Drug Resistance, Fungal
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Landscape of essential growth and fluconazole-resistance genes in the human fungal pathogen Cryptococcus neoformans.
PLoS biology
May 22, 2025
Fungi can cause devastating invasive infections, typically in immunocompromised patients. Treatment is complicated both by the evolutionary similarity between humans and fungi and by the frequent emergence of drug resistance. Studies in fungal pathog...
Antifungal activity and mechanism of novel peptide antimicrobial peptide (GmAMP) against fluconazole-resistant .
PeerJ
May 20, 2025
BACKGROUND: There is a pressing need to create innovative alternative treatment approaches considering the overuse of antifungal drugs causes the number of clinically isolated fluconazole-resistant species to increase. antimicrobial peptide (GmAMP)...
ML-AMPs designed through machine learning show antifungal activity against C. albicans and therapeutic potential on mice model with candidiasis.
Life sciences
Feb 19, 2025
AIMS: C. albicans resistant strains have led to increasingly severe treatment challenges. Antimicrobial peptides with low resistance-inducing propensity for pathogens have been developed. A series of antimicrobial peptides de novo designed through ma...
Application of Raman spectroscopy and machine learning for identification and characterization.
Applied and environmental microbiology
Oct 29, 2024
UNLABELLED: an emerging fungal pathogen characterized by multidrug resistance and high-mortality nosocomial infections, poses a serious global health threat. However, the precise and rapid identification and characterization of remain a challenge. ...
Coupling machine learning and epidemiological modelling to characterise optimal fungicide doses when fungicide resistance is partial or quantitative.
Journal of the Royal Society, Interface
Apr 19, 2023
Increasing fungicide dose tends to lead to better short-term control of plant diseases. However, high doses select more rapidly for fungicide resistant strains, reducing long-term disease control. When resistance is qualitative and complete-i.e. resi...
Piperidine based 1,2,3-triazolylacetamide derivatives induce cell cycle arrest and apoptotic cell death in .
Journal of advanced research
Nov 10, 2020
The fungal pathogen , is a serious threat to public health and is associated with bloodstream infections causing high mortality particularly in patients with serious medical problems. As this pathogen is generally resistant to all the available clas...
AI in fungal drug development: opportunities, challenges, and future outlook.
Frontiers in cellular and infection microbiology
Jan 1, 2025
The application of artificial intelligence (AI) in fungal drug development offers innovative strategies to address the escalating threat of fungal infections and the challenge of antifungal resistance. This review evaluates the current landscape of f...
From patterns to prediction: machine learning and antifungal resistance biomarker discovery.
Canadian journal of microbiology
Jan 1, 2025
Fungal pathogens significantly impact human health, agriculture, and ecosystems, with infections leading to high morbidity and mortality, especially among immunocompromised individuals. The increasing prevalence of antifungal resistance (AFR) exacerb...
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