Distinct Disconnection Patterns Explain Task-Specific Motor Impairment and Outcome After Stroke.

Journal: Stroke
Published Date: Aug 1, 2025

Abstract

BACKGROUND: Stroke is increasingly understood as a network disorder with symptoms often arising from disruption of white matter connectivity. Previous connectome-based lesion-symptom mapping studies revealed that poststroke motor deficits are not only associated with damage to the core sensorimotor network but also with nonsensorimotor connections. However, whether task-specific initial impairment and outcome are based on distinct disconnection patterns remains unknown.

Authors

  • Frauke Esser
    Medical Faculty, Department of Neurology, University Hospital Cologne, University of Cologne, Germany. (F.E., T.P., E.B., L.H., A.K.R., C.R., A.S., G.R.F., L.J.V.).
  • Theresa Paul
    Medical Faculty, Department of Neurology, University Hospital Cologne, University of Cologne, Germany. (F.E., T.P., E.B., L.H., A.K.R., C.R., A.S., G.R.F., L.J.V.).
  • Elizabeth Rizor
    Department of Psychological and Brain Sciences, University of California, Santa Barbara. (E.R., S.T.G.).
  • Ellen Binder
    Medical Faculty, Department of Neurology, University Hospital Cologne, University of Cologne, Germany. (F.E., T.P., E.B., L.H., A.K.R., C.R., A.S., G.R.F., L.J.V.).
  • Lukas Hensel
    Medical Faculty, Department of Neurology, University Hospital Cologne, University of Cologne, Germany. (F.E., T.P., E.B., L.H., A.K.R., C.R., A.S., G.R.F., L.J.V.).
  • Anne K Rehme
    Department of Neurology, University of Cologne, Cologne, Germany.
  • Corinna Ringmaier
    Medical Faculty, Department of Neurology, University Hospital Cologne, University of Cologne, Germany. (F.E., T.P., E.B., L.H., A.K.R., C.R., A.S., G.R.F., L.J.V.).
  • Anna Schönberger
    Medical Faculty, Department of Neurology, University Hospital Cologne, University of Cologne, Germany. (F.E., T.P., E.B., L.H., A.K.R., C.R., A.S., G.R.F., L.J.V.).
  • Caroline Tscherpel
    Zentrum der Neurologie und Neurochirurgie, Universitätsklinikum Frankfurt, Frankfurt, Deutschland.
  • Simone Vossel
    Faculty of Human Sciences, Department of Psychology, University of Cologne, Germany. (S.V.).
  • Frank E Garcea
    Department of Neurosurgery, University of Rochester Medical Center, NY. (F.E.G.).
  • Christian Grefkes
    Department of Neurology, University of Cologne, Cologne, Germany.
  • Gereon R Fink
    Department of Neurology, University of Cologne, Cologne, Germany.
  • Scott T Grafton
    Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106, USA.
  • Lukas J Volz
    Department of Neurology, University of Cologne, Cologne, Germany.

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