Identification of m5C RNA modification-related gene signature for predicting prognosis and immune microenvironment-related characteristics of heart failure.

Journal: Hereditas
Published Date: May 22, 2025

Abstract

BACKGROUND: Methylation of RNA is involved in many pathophysiological processes. The roles of N6-methyladenosine (m6A) and N7-methylguanosine (m7G) in heart failure (HF) have been established. However, the impact of 5-methylcytosine (m5C) on HF and its relationship with the immune microenvironment (IME) remains elusive.

Authors

  • Zirui Liu
    Speech, Hearing, and Phonetic Sciences, University College London, London, WC1N 1PJ, United Kingdom.
  • Rui Feng
    Department of Pharmacy, The Fourth Hospital of Hebei Medical University Shijiazhuang 050000, Hebei, China.
  • Ying Xu
    School of Biological and Food Engineering Changzhou University Changzhou Jiangsu China.
  • Meili Liu
    Cardiology Department, First Affiliated Hospital of Soochow University, 188 Shizi Street, Gusu District, Suzhou, Jiangsu Province, 215006, China.
  • Haocheng Wang
    Department of Psychology and the Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
  • Yu Lu
    Faw-volkswagen Automative Co., Changchun, China.
  • Weiqi Wang
  • Jikai Wang
    Cardiology Department, First Affiliated Hospital of Soochow University, 188 Shizi Street, Gusu District, Suzhou, Jiangsu Province, 215006, China.
  • Cao Zou
    Cardiology Department, First Affiliated Hospital of Soochow University, 188 Shizi Street, Gusu District, Suzhou, Jiangsu Province, 215006, China. nkzc75@suda.edu.cn.

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