Identification of diagnostic genes for myocardial ischemia reperfusion injury associated with metabolic syndrome through the integration of bioinformatics analysis, molecular docking and experimental validation.

Journal: Frontiers in immunology
Published Date: May 29, 2025

Abstract

BACKGROUND: Metabolic dysregulation in metabolic syndrome (MetS) exacerbates myocardial ischemia-reperfusion injury (MIRI). This study aimed to identify diagnostic biomarkers and therapeutic candidates for MetS-associated MIRI.

Authors

  • Shufang Liu
    School of Public Health, Hebei University Health Science Center, Baoding, China.
  • Yan Zhang
    Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China.
  • Yanan Zhao
    Department of Oncology and Hematology Surgery, China-Japan Union Hospital, Changchun, Jilin Province, China.
  • Ping Wu
  • Shouyuan Tian
    Department of Anesthesiology, Shanxi Provincial People's Hospital, Taiyuan, China.
  • Han-Qing Pang
    Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, China.
  • Zhifang Wu
    Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.
  • Sijin Li
    Shanxi Medical University, Taiyuan 030009, PR China; Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, PR China; Collaborative Innovation Center for Molecular Imaging, Taiyuan 030001, PR China. Electronic address: lisjnm123@163.com.

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