Immunological biomarkers and gene signatures predictive of radiotherapy resistance in non-small cell lung cancer.

Journal: Frontiers in immunology
Published Date: May 29, 2025

Abstract

INTRODUCTION: A significant challenge in treating non-small cell lung cancer (NSCLC) is its inherent resistance to radiation therapy, leading to poor patient prognosis. This study aimed to identify key genes influencing radiotherapy resistance in NSCLC through comprehensive bioinformatics analysis.

Authors

  • Jie Lv
    Center for Bioinformatics and Computational Biology, Houston Methodist Research Institute, Houston, TX, USA.
  • Chun-Yang Yu
    Department of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.
  • Yao-Zu Xiong
    Department of Radiotherapy, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.
  • Ting-Ting Dai
    Department of Radiotherapy, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.
  • Xiao-Chu Hu
    Department of Radiotherapy, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.
  • Peng Pan
    Department of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
  • Shun Yue
    Department of Oncology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.
  • Chang-Hua Yu
    Department of Radiotherapy, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.

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