TRAF3 as a potential diagnostic biomarker for recurrent pregnancy loss: insights from single-cell transcriptomics and machine learning.

Journal: BMC pregnancy and childbirth
Published Date:

Abstract

BACKGROUND: Recurrent pregnancy loss (RPL), characterized by multiple miscarriages, remains a condition with unclear etiology, posing significant challenges for affected women and couples. This study aims to explore the underlying mechanisms of RPL, focusing on the role of decidual Natural Killer (dNK) cells and the TNF receptor-associated factor 3 (TRAF3) gene as a potential diagnostic marker and therapeutic target.

Authors

  • Yi-Bo He
    Department of Clinical Lab, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.
  • Jun-Yu Li
    Department of Pharmacy, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
  • Shi-Liang Chen
    Department of Clinical Lab, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.
  • Rui Ye
    School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen 518055, Guangdong, China.
  • Yi-Ran Fei
    The First Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang Province, China.
  • Shi-Yuan Tong
    State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
  • Yu-Xuan Song
    College of Forensic Science, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.
  • Cong Wang
    Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Li Zhang
    Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  • Ju Fang
    Reproductive Center, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, China.
  • Yue Shang
    Department of Endocrinology, Shenzhen Children's Hospital, No. 7019, Yitian Road, Futian District, Shenzhen, 518038, Guangdong Province, People's Republic of China.
  • Zhe-Zhong Zhang
    Department of Clinical Lab, The First Affiliated Hospital of Zhejiang Chinese Medical University, (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, China.
  • Jin Chen
    Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX.
  • Ai-Zhong Yang
    Reproductive Center, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
  • Jie Liu
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.
  • Yong-Lin Liu
    Reproductive Center, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China. liu3319@126.com.