Gray Matter Differences in Adolescent Psychiatric Inpatients: A Machine Learning Study of Bipolar Disorder and Other Psychopathologies.

Journal: Brain and behavior
Published Date: Jun 1, 2025

Abstract

BACKGROUND: Bipolar disorder (BD) is among the psychiatric disorders most prone to misdiagnosis, with both false positives and false negatives resulting in treatment delay. We employed a whole-brain machine learning approach focusing on gray matter volumes (GMVs) to contribute to defining objective biomarkers of BD and discriminating it from other forms of psychopathology, including subthreshold manic presentations without a BD Type I/II diagnosis.

Authors

  • Renata Rozovsky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Maria Wolfe
    Western Psychiatric Hospital, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA.
  • Halimah Abdul-Waalee
    Western Psychiatric Hospital, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA.
  • Mariah Chobany
    Western Psychiatric Hospital, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA.
  • Greeshma Malgireddy
    Western Psychiatric Hospital, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA.
  • Jonathan A Hart
    Western Psychiatric Hospital, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA.
  • Brianna Lepore
    Western Psychiatric Hospital, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA.
  • Farzan Vahedifard
    From the Department of Diagnostic Radiology and Nuclear Medicine (F.V., X.L., J.O.A., K.K.M., S.E.B.), Rush Medical College, Chicago, Illinois.
  • Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
  • Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
  • Alex Skeba
    Western Psychiatric Hospital, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, USA.
  • Rasim S Diler
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Michele A Bertocci
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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