Terahertz molecular vibrational sensing using 3D printed anapole meta-biosensor.

Journal: Biosensors & bioelectronics
Published Date: Mar 7, 2025

Abstract

Terahertz (THz) fingerprint sensing utilizes the absorption of fingerprints generated by the unique vibrational characteristics of molecules to achieve substance-specific identification. By taking full advance of the anapole mode induced-biosensor consisting of out-of-plane metal-insulator-metal (MIM) configuration, the D-glucose solutions down to physiological level are accurately detected by proposed metasurface biosensor through the electromagnetic induced absorption (EIA) effect induced by the interaction between the metasurface and molecular vibrational fingerprint. Besides, by utilizing the vibrational fingerprint sensing ability, the pure D-glutamic acid and D-lactose, as well as their mixture have been quantitatively characterized. In addition, with the aid of machine learning algorithms, the designed single resonance metasensor achieves 100% recognition of five molecules. This work brings a convincing strategy for trace label-free molecular recognition for various species, which might extend the promising potentials of THz sensing techniques toward biomedical testing and clinical diagnosis.

Authors

  • Chenglin Yang
    School of Automation Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China.
  • Zhonglei Shen
    School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China; Centre for Disruptive Photonic Technologies, Division of Physics and Applied Physics School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore. Electronic address: zlshen@xjtu.edu.cn.
  • Yuqing Cui
    State Key Laboratory of Experimental Hematology, Hematopoietic Stem Cell Transplantation Center, Haihe Laboratory of Cell Ecosystem, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
  • Nan Zhang
    Department of Pulmonary and Critical Care Medicine II, Emergency General Hospital, Beijing, China.
  • Liuyang Zhang
    Department of Thyroid Surgery, Affiliated Hospital of Chengde Medical University, Chengde, Hebei Province, China.
  • Ruqiang Yan
    Xi'an Jiaotong University, PR China; School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, 710049, PR China; State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, 710049, PR China. Electronic address: yanruqiang@xjtu.edu.cn.
  • Xuefeng Chen
    Xi'an Jiaotong University, PR China; School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, 710049, PR China; State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, 710049, PR China. Electronic address: chenxf@xjtu.edu.cn.

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