Association between metal mixture in urine and abnormal blood pressure and mediated effect of oxidative stress based on BKMR and Machine learning method.

Journal: Ecotoxicology and environmental safety
Published Date: Aug 1, 2025

Abstract

BACKGROUND: Exposure to heavy metals represents a significant risk factor for hypertension and blood pressure disorders. Notably, current evidence indicates that the key biological processes of oxidative stress, inflammation, and endothelial dysfunction are related to metal exposure and blood pressure dysregulation, ultimately contributing to cardiovascular pathogenesis. However, their underlying biological mechanisms remain incompletely characterized.

Authors

  • Junjie Chen
    College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan, China.
  • Hao Zeng
    European Laboratory for Non Linear Spectroscopy (LENS), University of Florence, 50019 Sesto Fiorentino, Italy.
  • Zhanglei Pan
    School of Aerospace Engineering, Civil Aviation University of China, No. 2898, Jinbei Road, Dongli District, Jinshi 300300, China.
  • Miao Li
    School of Computer Science and TechnologyHuazhong University of Science and Technology Wuhan 430074 China.
  • Qingfeng Zhou
    School of Public Health, North China University of Science and Technology, No.21 Bohai Road, Caofeidian, Tangshan, Hebei 063210, China.
  • Kaichen Chen
    School of Public Health, North China University of Science and Technology, No.21 Bohai Road, Caofeidian, Tangshan, Hebei 063210, China.
  • Yulan Hao
    School of Public Health, North China University of Science and Technology, No.21 Bohai Road, Caofeidian, Tangshan, Hebei 063210, China.
  • Xiangke Cao
    College of Life Science, North China University of Science and Technology, Tangshan, Hebei 063000, China.
  • Lei Zhang
    Division of Gastroenterology, Union Hospital, Tongji Medical College Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Qian Wang
    Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, China.

Keywords

External Resources

Popular Topics
Recent Journals