Effectiveness and safety of blonanserin for improving social and cognitive functions in patients with first-episode schizophrenia: a study protocol for a prospective, multicentre, single-arm clinical trial.

Journal: BMJ open
PMID:

Abstract

INTRODUCTION: Both the pharmacological characteristics of blonanserin and its related small sample size studies suggest that blonanserin could alleviate social and cognitive dysfunctions in patients with schizophrenia. However, no large sample size studies have been performed so far. This study aimed to investigate the effectiveness and safety of blonanserin in improving social and cognitive functions in patients with first-episode schizophrenia.

Authors

  • Chengcheng Pu
    Department of Clinical Research, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
  • Lei Lei
    Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Fude Yang
    Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.
  • Hong Deng
    Mental Health Center, West China Hospital of Sichuan University, Chengdu, China.
  • Jianhua Sheng
    Department of Psychiatry, Shanghai Mental Health Center, Shanghai, China.
  • Zhening Liu
    Mental Health Institute, the Second Xiangya Hospital of Central South University, Changsha, China.
  • Shaohua Hu
    Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Mental Disorder's Management of Zhejiang Province, Zhejiang Engineering Center for Mathematical Mental Health, Hangzhou, Zhejiang, China.
  • Lina Wang
    Department of Biochemistry and Molecular Biology, Shandong University School of MedicineJinan, P. R. China; Central Laboratory, The Second Hospital of Shandong UniversityJinan, P. R. China.
  • Bin Wu
    Department of Psychiatry, Xi'an Mental Health Center, Xi'an, China.
  • Qijing Bo
    Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, China.
  • Yoshifumi Inoue
    Medical Affairs Department, Sumitomo Dainippon Pharma Co, Osaka, Japan.
  • Xin Yu
    eSep Inc., Keihanna Open Innovation Center @ Kyoto (KICK), Annex 320, 7-5-1, Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0238, Japan.