Development and validation of an interpretable machine learning model for predicting Philadelphia chromosome-positive acute lymphoblastic leukaemia using clinical and laboratory parameters: a single-centre retrospective study.

Journal: BMJ open
Published Date:

Abstract

OBJECTIVE: To develop and validate a prediction model of Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ALL).

Authors

  • Wuchen Yang
    Shanghai Key Lab of Modern Optical System, School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, 20093, Shanghai, China. Electronic address: yangmiemieywc@163.com.
  • Jingya Liu
    Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Chongqing, China.
  • Yang Gou
    Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Chongqing, China.
  • Xingqin Huang
    Department of Hematology, Third Military Medical University Southwest Hospital, Chongqing, China.
  • Maoshan Chen
    Laboratory of Radiation Biology, Department of Blood Transfusion, Laboratory Medicine Center, Third Military Medical University Second Affiliated Hospital, Chongqing, China.
  • Dezhi Huang
    Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Chongqing, China.
  • Shengwang Wu
    Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Chongqing, China.
  • Jing Zhang
    MOEMIL Laboratory, School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu, China.
  • Cheng Zhang
    College of Forestry, Jiangxi Agricultural University, Nanchang, Jiangxi Province, China.
  • Shuiqing Liu
    Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Chongqing, China liushuiqing062@tmmu.edu.cn pxg1964@136.com zhangxxi@sina.com.
  • Xiangui Peng
    Department of Hematology, The Xinqiao Hospital of Army Medical University, Chongqing, China.
  • Xi Zhang
    The First Clinical Medical College, Guangxi University of Chinese Medicine, Nanning 530001, China.