Precision Strike Strategy for Liver Diseases Trilogy with Xiao-Chai-Hu Decoction: A Meta-Analysis with Machine Learning.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology
Published Date: Apr 23, 2025

Abstract

BACKGROUND AND PURPOSE: The progression from hepatitis to liver fibrosis (LF) and ultimately to hepatic carcinoma (HCC) represents the advanced stages of various liver diseases. Currently, no universal treatment effectively addresses all three conditions. The Traditional Chinese Medicine formula Xiao-Chai-Hu decoction (XCHD) has shown promise in treating hepatitis, inhibiting LF, and serving as an adjunct therapy for HCC. This study evaluates the efficacy and optimal treatment durations of XCHD in managing these liver diseases using meta-analysis and machine learning techniques.

Authors

  • Zexin Wang
  • Yubing Li
    School of Science, Chongqing University of Posts and Telecommunications, Chongqing, China.
  • Xiaobao Wang
    College of Intelligence and Computing, Tianjin University, Tianjin, China. Electronic address: wangxiaobao@tju.edu.cn.
  • Wenwen Zhang
    Rutgers, the State University of New Jersey, New Brunswick, NJ, USA.
  • Yuan Chen
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032.
  • Xiaohua Lu
    Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
  • Chunmei Jin
    Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
  • Lang Tu
    West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
  • Tao Jiang
    Department of Respiratory and Critical Care Medicine, Center for Respiratory Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
  • Yiqin Yang
    The Second School of Clinical Medicine, Shandong University, Jinan, China.
  • Xiao Ma
    Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Jinhao Zeng
    TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. Electronic address: zengjinhao@cdutcm.edu.cn.
  • Yueqiang Wen
    School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China. Electronic address: wenyueqiang@cdutcm.edu.cn.
  • Thomas Efferth
    Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Germany.

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