Refining early detection of Marburg Virus Disease (MVD) in Rwanda: Leveraging predictive symptom clusters to enhance case definitions.

Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Published Date: Apr 3, 2025

Abstract

BACKGROUND: Marburg Virus Disease (MVD) poses a significant global health risk due to its high case fatality rates (24%-88%) and the diagnostic challenges posed by its nonspecific early symptoms, which overlap with other febrile illnesses like malaria. This study analyzed symptom patterns from the 2024 MVD outbreak in Rwanda to refine case definitions and enhance early detection.

Authors

  • Olivier Nsekuye
    Rwanda Biomedical Centre, Kigali, Rwanda; Adventist University of Central Africa (AUCA), Kigali, Rwanda. Electronic address: nsekuye.olivier003@gmail.com.
  • Frederick Ntabana
    Rwanda Biomedical Centre, Kigali, Rwanda.
  • Hugues Valois Mucunguzi
    Rwanda Biomedical Centre, Kigali, Rwanda.
  • Ziad El-Khatib
    Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
  • Eric Remera
    Rwanda Biomedical Centre, Kigali, Rwanda.
  • Lyndah Makayotto
    World Health Organization, Kigali, Rwanda.
  • Menelas Nkeshimana
    Rwanda Ministry of Health, Kigali, Rwanda.
  • David Turatsinze
    The University Teaching Hospital of Kigali (CHUK), Kigali, Rwanda.
  • Frederic Ntirenganya
    Rwanda Biomedical Centre, Kigali, Rwanda.
  • Semakula Muhammed
    Rwanda Ministry of Health, Kigali, Rwanda.
  • Athanase Rukundo
    Rwanda Ministry of Health, Kigali, Rwanda.
  • Brian Chirombo
    World Health Organization, Kigali, Rwanda.
  • Richard Muvunyi
    Rwanda Development Board (RDB), Kigali, Rwanda.
  • Claude Mambo Muvunyi
    Rwanda Biomedical Centre, Kigali, Rwanda.
  • Pacifique Nizeyimana
    Adventist University of Central Africa (AUCA), Kigali, Rwanda.
  • Yvan Butera
    Rwanda Ministry of Health, Kigali, Rwanda.
  • Sabin Nsanzimana
    Rwanda Ministry of Health, Kigali, Rwanda.
  • Edson Rwagasore
    Rwanda Biomedical Centre, Kigali, Rwanda.

Keywords

External Resources

Popular Topics
Recent Journals