Dual-Modality Virtual Biopsy System Integrating MRI and MG for Noninvasive Predicting HER2 Status in Breast Cancer.

Journal: Academic radiology
Published Date: Mar 10, 2025

Abstract

RATIONALE AND OBJECTIVES: Accurate determination of human epidermal growth factor receptor 2 (HER2) expression is critical for guiding targeted therapy in breast cancer. This study aimed to develop and validate a deep learning (DL)-based decision-making visual biomarker system (DM-VBS) for predicting HER2 status using radiomics and DL features derived from magnetic resonance imaging (MRI) and mammography (MG).

Authors

  • Qian Wang
    Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, China.
  • Zi-Qian Zhang
    Department of Radiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu Province, China (Z.-Q.Z.).
  • Can-Can Huang
    Department of Radiology, The Affiliated Huai'an Clinical College of Xuzhou Medical University, Huai'an, Jiangsu Province, China (Q.W., C.-C.H., H.-W.X., G.-J.B.).
  • Hong-Wang Xue
    Department of Radiology, The Affiliated Huai'an Clinical College of Xuzhou Medical University, Huai'an, Jiangsu Province, China (Q.W., C.-C.H., H.-W.X., G.-J.B.).
  • Hui Zhang
    Department of Pulmonary Vessel and Thrombotic Disease, Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Fan Bo
    Department of Radiology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China (H.Z., F.B., W.-T.G., W.Z.).
  • Wen-Ting Guan
    Department of Radiology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China (H.Z., F.B., W.-T.G., W.Z.).
  • Wei Zhou
    Department of Eye Function Laboratory, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
  • Gen-Ji Bai
    Department of Radiology, The Affiliated Huai'an Clinical College of Xuzhou Medical University, Huai'an, Jiangsu Province, China (Q.W., C.-C.H., H.-W.X., G.-J.B.). Electronic address: hybgj0451@163.com.

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