Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction.

Journal: Biological psychiatry
Published Date:

Abstract

BACKGROUND: Opioid addiction is a worldwide public health crisis. In the United States, for example, opioids cause more drug overdose deaths than any other substance. However, opioid addiction treatments have limited efficacy, meaning that additional treatments are needed.

Authors

  • Kyle A Sullivan
    Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee.
  • David Kainer
    DOE Center for Bioenergy Innovation, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN37831, United States.
  • Matthew Lane
    The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee-Knoxville, Knoxville, Tennessee.
  • Mikaela Cashman
    Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California.
  • J Izaak Miller
    Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee.
  • Michael R Garvin
    Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee.
  • Alice Townsend
    The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee-Knoxville, Knoxville, Tennessee.
  • Bryan C Quach
    RTI International, Research Triangle Park, North Carolina.
  • Caryn Willis
    RTI International, Research Triangle Park, North Carolina.
  • Peter Kruse
    The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee-Knoxville, Knoxville, Tennessee.
  • Nathan C Gaddis
    RTI International, Research Triangle Park, North Carolina.
  • Ravi Mathur
    RTI International, Research Triangle Park, North Carolina.
  • Olivia Corradin
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  • Brion S Maher
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
  • Peter C Scacheri
    Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio.
  • Sandra Sanchez-Roige
    Department of Psychiatry, University of California San Diego, La Jolla.
  • Abraham A Palmer
    Department of Psychiatry, University of California San Diego, La Jolla, California; Institute for Genomic Medicine, University of California San Diego, La Jolla, California.
  • Vanessa Troiani
    Autism and Developmental Medicine Institute, Geisinger, Danville, PA, United States.
  • Elissa J Chesler
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 USA.
  • Rachel L Kember
    Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Henry R Kranzler
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania & VISN4 MIRECC, Crescenz VAMC, Philadelphia, PA 19104, USA.
  • Amy C Justice
    Department of Internal Medicine, Yale University School of Medicine, New Haven.
  • Ke Xu
    Mechatronics Engineering of University of Electronic Science and Technology of China, Chengdu, 611731, China.
  • Bradley E Aouizerat
    Translational Research Center, College of Dentistry, New York University, New York, New York, USA.
  • Dana B Hancock
    RTI International, Research Triangle Park, North Carolina. Electronic address: dhancock@rti.org.
  • Eric O Johnson
    RTI International, Research Triangle Park, North Carolina; Fellow Program, RTI International, Research Triangle Park, North Carolina. Electronic address: ejohnson@rti.org.
  • Daniel A Jacobson
    Oak Ridge National Laboratory, Oak Ridge, Tennessee.