Machine learning-based integration identifies plasma cells-related gene signature ST6GAL1 in idiopathic pulmonary fibrosis.

Journal: BMC pulmonary medicine
Published Date: Jul 2, 2025

Abstract

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare, progressive, and fibrotic disease with poor prognosis that lacks treatment options. As a major component of the lung adaptive immune system, plasma cells play a crucial regulatory role during fibrosis. The aim of this study is to systematically explore plasma cells-related genes associated with prognosis in patients with IPF.

Authors

  • Fanjie Lin
    State Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
  • Ken Lin
    Department of Otorhinolaryngology, The Affiliated Children's Hospital of Kunming Medical University, Kunming, China.
  • Donglei Li
    Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
  • Weiguo Kong
    State Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
  • Jiayu Zhuang
    State Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
  • Wei He
    Department of Orthopaedics Surgery, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
  • Xinguang Wei
    State Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
  • Tianchi Xiao
    Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
  • Hao Zu
    Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
  • Zili Zhang
    College of Computer and Information Science, Southwest University, Chongqing 400715, China.
  • Wenju Lu
    State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

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