Tumor-Intrinsic and Microenvironmental Determinants of Impaired Antitumor Immunity in Chromophobe Renal Cell Carcinoma.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Published Date:

Abstract

PURPOSE: While immune checkpoint inhibition (ICI) has transformed the management of many advanced renal cell carcinomas (RCCs), the determinants of effective antitumor immunity for chromophobe RCC (ChRCC) and renal oncocytic tumors remain an unmet clinical and scientific need.

Authors

  • Chris Labaki
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Broad Institute, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Eddy Saad
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Katrine N Madsen
    Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT.
  • Charbel Hobeika
    Department of Medicine, Cleveland Clinic Fairview Hospital, Cleveland, OH.
  • Kevin Bi
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Broad Institute, Cambridge, MA, USA.
  • Michel Alchoueiry
    Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Sabrina Camp
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Yue Hou
    College of Metropolitan Transportation, Beijing University of Technology, Beijing 100124, China.
  • Ziad Bakouny
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Sayed Matar
    Department of Pathology, Brigham and Women's Hospital, Boston, MA.
  • Nourhan El Ahmar
    Department of Pathology, Brigham and Women's Hospital, Boston, MA.
  • Jackson Nyman
    Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Long Zhang
    Hefei Institute of Physical Science, Chinese Academy of Sciences Hefei 230036 PR China liuyong@aiofm.ac.cn zhanglong@aiofm.ac.cn wangchongwen1987@126.com.
  • Carmen Priolo
    Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Rishabh Rout
    Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT.
  • Melissa Daou
    Department of Medicine, Yale University, New Haven, CT.
  • Damir Khabibullin
    Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Samer Salem
    Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Nicholas Schindler
    Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT.
  • Renée Maria Saliby
    Center of Molecular and Cellular Oncology (CMCO), Yale School of Medicine, New Haven, CT.
  • Kevin Meli
    Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • J Connor Wells
    BC Cancer Agency, Vancouver, Canada.
  • Erica Pimenta
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Kosuke Takemura
    Shiga University Faculty of Economics, 1-1-1 Banba, Hikone, Shiga, 522-8522, Japan.
  • Jihye Park
    Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, 11794, USA.
  • Marc Eid
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Karl Semaan
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Jingxin Fu
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Thomas Denize
    Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
  • Razane El Hajj Chehade
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Marc Machaalani
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Rashad Nawfal
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Wassim Daoud Khatoun
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Mustafa Saleh
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Jad El Masri
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Nina Rossa Haddad
    Johns Hopkins University School of Medicine, Baltimore, MD.
  • Wenxin Xu
    From Dana-Farber Cancer Institute, Boston, MA, USA.
  • Bradley A McGregor
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
  • Michelle S Hirsch
    Department of Pathology, Brigham and Women's Hospital, Boston, MA.
  • Wanling Xie
    Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Daniel Y C Heng
    Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.
  • David F McDermott
    Department of Medical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
  • Sabina Signoretti
    Broad Institute, Cambridge, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Eliezer M Van Allen
    Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Harvard University, Boston, Massachusetts.
  • Sachet A Shukla
    Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Texas, Houston, TX.
  • Toni K Choueiri
    Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
  • Elizabeth P Henske
    Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • David A Braun
    Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.