Evolution of Cortical Lesions and Function-Specific Cognitive Decline in People With Multiple Sclerosis.

Journal: Neurology
PMID: 40354586

Abstract

BACKGROUND AND OBJECTIVES: Cortical lesions in multiple sclerosis (MS) severely affect cognition, but their longitudinal evolution and impact on specific cognitive functions remain understudied. This study investigates the evolution of function-specific cognitive functioning over 10 years in people with MS and assesses the influence of cortical lesion load and formation on these trajectories.

Authors

  • Eva A Krijnen
    MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
  • Julia Jelgerhuis
    MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
  • Maureen Van Dam
    MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
  • Piet M Bouman
    MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
  • Frederik Barkhof
    MS Center Amsterdam, Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
  • Eric C Klawiter
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Hanneke E Hulst
    Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, the Netherlands.
  • Eva M M Strijbis
    MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
  • Menno M Schoonheim
    MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.

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