Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery.

Journal: Molecular medicine (Cambridge, Mass.)
Published Date: Jul 5, 2025

Abstract

BACKGROUND: Acute pancreatitis (AP) is a severe inflammatory disease frequently accompanied by disturbances in glucose metabolism, which further complicate the disease prognosis. This study aims to explore the role of PFKFB3, a key glycolytic enzyme, in regulating glucose metabolism in AP and assess the potential of PFKFB3 inhibition via nanovesicle delivery to mitigate metabolic dysfunction.

Authors

  • Hai Jiang
    Department of Obstetrics and Gynecology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
  • Zhipeng Xu
    Institute of Photoelectronic Thin Film Devices and Technology, Nankai University, Tianjin, 300350, P. R. China.
  • Qi Song
    ‡ College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Junjie Tao
    Department of Emergency Surgery, the First Affiliated Hospital of Bengbu Medical University, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, China.
  • Jia Liu
    Department of Colorectal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin, China.
  • Qiang Wang
    Ningbo Konfoong Bioinformation Tech Co., Ltd, Ningbo, China.
  • Huaisheng Zhang
    Department of Emergency Surgery, the First Affiliated Hospital of Bengbu Medical University, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, China.
  • Heng Zhu
    Department of Emergency Surgery, the First Affiliated Hospital of Bengbu Medical University, No. 287, Changhuai Road, Bengbu, 233000, Anhui Province, China.
  • Qiliang Li
    Department of Electrical and Computer Engineering, George Mason University, Fairfax, VA 22030, USA.
  • Lei Li
    Department of Thoracic Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China.

Keywords

External Resources

Popular Topics
Recent Journals