Whole‑exome evolutionary profiling of osteosarcoma uncovers metastasis‑related driver mutations and generates an independently validated predictive classifier.

Journal: Journal of translational medicine
Published Date: Jul 7, 2025

Abstract

BACKGROUND: Osteosarcoma is the most common primary malignant bone tumor, with high invasiveness and metastatic potential and a poor prognosis in patients with metastatic cancer. Despite the rapid advancements in genomics in recent years that provided new perspectives for studying the molecular mechanisms of osteosarcoma, the understanding of its tumor heterogeneity and evolutionary mutation process remains limited.

Authors

  • Zhen Wang
    Department of Otolaryngology, Longgang Otolaryngology hospital & Shenzhen Key Laboratory of Otolaryngology, Shenzhen Institute of Otolaryngology, Shenzhen, Guangdong, China.
  • Zhe Wang
    Department of Pathology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
  • Ruoyu Wang
    Institute of Public Health and Wellbeing, University of Essex, Essex, UK.
  • Zumin Wang
    Graduate School, Dalian University, Dalian, Liaoning 116622, P. R. China.
  • Xiangyang Cao
    Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Zhengzhou, Henan, China.
  • Rui Chen
    College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shanxi, China.
  • Zebing Ma
    Hunan University of Chinese Medicine, Changsha, Hunan, China.
  • Shanshan Liang
    The Key Laboratory of Biomarker High-Throughput Screening and Target Translation of Breast and Gastrointestinal Tumors, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China. liangshanshan@dlu.edu.cn.
  • Shuai Tao
    Dalian Key Laboratory of Smart Medical and Health, Dalian University, Dalian, Liaoning 116622, P. R. China.

Keywords

External Resources

Popular Topics
Recent Journals