Niuhuang jiedu prescription alleviates realgar-induced dopaminergic and GABAergic neurotoxicity in Caenorhabditis elegans.

Journal: Journal of ethnopharmacology
PMID: 40185261

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Niuhuang Jiedu (NHJD) is a Chinese medicine prescription containing realgar (AsS), which is neurotoxic, and seven other traditional Chinese medicines (TCMs). However, whether the multiple TCMs contained in NHJD can mitigate the neurotoxicity of realgar is yet to be elucidated.

Authors

  • Ying Wang
    Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.
  • Linjuan Du
    School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Lingyue Zou
    School of Elderly Care Services and Management, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Xiaowei Chen
    School of Elderly Care Services and Management, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Jiansheng Zhu
    Department of Infectious Diseases, Affiliated Taizhou Hospital of Wenzhou Medical University, No.50 Ximeng Road, Taizhou, 317000, China. jianshengzzhu@sina.cn.
  • Qinli Ruan
    School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address: Ruanql1977@sina.com.cn.
  • Guochun Li
    School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address: liguochuncn@126.com.
  • Ju Dong
    School of Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address: 290014@njucm.edu.cn.

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