Specific Contribution of the Cerebellar Inferior Posterior Lobe to Motor Learning in Degenerative Cerebellar Ataxia.

Journal: Cerebellum (London, England)
Published Date: Jul 16, 2025

Abstract

BACKGROUND AND OBJECTIVE: Degenerative cerebellar ataxia, a group of progressive neurodegenerative disorders, is characterised by cerebellar atrophy and impaired motor learning. Using CerebNet, a deep learning algorithm for cerebellar segmentation, this study investigated the relationship between cerebellar subregion volumes and motor learning ability.

Authors

  • Kyota Bando
  • Takeru Honda
  • Kinya Ishikawa
    The Center for Personalized Medicine for Healthy Aging, Institute of Science Tokyo (Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Shinichi Shirai
    Department of Neurology, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.
  • Ichiro Yabe
    Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
  • Tomohiko Ishihara
    Departments of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan.
  • Osamu Onodera
    Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8585, Japan.
  • Yuichi Higashiyama
    Department of Neurology and Stroke Medicine, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Kanagawa, Japan.
  • Fumiaki Tanaka
    Department of Neurology and Stroke Medicine, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Kanagawa, Japan.
  • Yoshiyuki Kishimoto
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya University, 65 Tsurumai-Cho, Showa-Ku, Nagoya, 466-8550, Japan.
  • Masahisa Katsuno
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya University, 65 Tsurumai-Cho, Showa-Ku, Nagoya, 466-8550, Japan.
  • Takahiro Shimizu
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago, 683-8504, Japan.
  • Ritsuko Hanajima
    Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago, 683-8504, Japan.
  • Takumi Kanata
    Department of Clinical Data Science, Clinical Research & Education Promotion Division, National Center of Neurology and Psychiatry, Tokyo, 187-8551, Japan.
  • Yuji Takahashi
    Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.
  • Hidehiro MizusawaMD
    Department of Neurology, National Center of Neurology and Psychiatry, National Center Hospital, 4-1-1 Ogawahigashicho, Kodaira, Tokyo, 187-8551, Japan. mizusawa@ncnp.go.jp.

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