Precision Symptom Phenotyping Identifies Early Clinical and Proteomic Predictors of Distinct COVID-19 Sequelae.

Journal: The Journal of infectious diseases
Published Date:

Abstract

BACKGROUND: Post-COVID conditions (PCC) are difficult to characterize, diagnose, predict, and treat due to overlapping symptoms and poorly understood pathology. Identifying inflammatory profiles may improve clinical prognostication and trial endpoints.

Authors

  • Nusrat J Epsi
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Josh G Chenoweth
    Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
  • Paul W Blair
    Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
  • David A Lindholm
    Division of Infectious Diseases, Brooke Army Medical Center, San Antonio, Texas, USA.
  • Anuradha Ganesan
    Department of Oral Medicine & Radiology, SRM Dental College, Bharathi Salai, Chennai, India.
  • Tahaniyat Lalani
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Alfred Smith
    Division of Infectious Diseases, Naval Medical Center Portsmouth, Portsmouth, Virginia, USA.
  • Rupal M Mody
    Division of Infectious Diseases, William Beaumont Army Medical Center, El Paso, Texas, USA.
  • Milissa U Jones
    Division of Infectious Diseases, Tripler Army Medical Center, Honolulu, Hawaii, USA.
  • Rhonda E Colombo
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Christopher J Colombo
    Division of Infectious Diseases, Madigan Army Medical Center, Tacoma, Washington, USA.
  • Christina Schofield
    Division of Infectious Diseases, Madigan Army Medical Center, Tacoma, Washington, USA.
  • Evan C Ewers
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Derek T Larson
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Catherine M Berjohn
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Ryan C Maves
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Anthony C Fries
    The Applied Technology and Genomics (PHT) Division, U.S. Air Force School of Aerospace Medicine, Dayton, Ohio, USA.
  • David Chang
    Yale Center for Medical Informatics, Yale University.
  • Andrew Wyatt
    Division of Infectious Diseases, Landstuhl Regional Medical Center, Landstuhl, Germany.
  • Ann I Scher
    Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Celia Byrne
    Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Jennifer Rusiecki
    Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • David L Saunders
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Jeffrey Livezey
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Allison Malloy
    Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Samantha Bazan
    Department of Primary Care, Carl R. Darnall Army Medical Center, Fort Cavazos, Texas, USA.
  • Carlos Maldonado
    Department of Clinical Investigation, Womack Army Medical Center, Fort Liberty, North Carolina, USA.
  • Margaret Sanchez Edwards
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Katrin Mende
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Mark P Simons
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Robert J O'Connell
    Department of Retrovirology, U.S. Army Medical Component, AFRIMS, Bangkok, Thailand.
  • David R Tribble
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Brian K Agan
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Timothy H Burgess
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Simon D Pollett
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
  • Stephanie A Richard
    Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.