Diagnostic accuracy of ChatGPT-4 in orthopedic oncology: a comparative study with residents.

Journal: The Knee
Published Date: May 1, 2025

Abstract

BACKGROUND: Artificial intelligence (AI) is increasingly being explored for its potential role in medical diagnostics. ChatGPT-4, a large language model (LLM) with image analysis capabilities, may assist in histopathological interpretation, but its accuracy in musculoskeletal oncology remains untested. This study evaluates ChatGPT-4's diagnostic accuracy in identifying musculoskeletal tumors from histology slides compared to orthopedic surgery residents.

Authors

  • Hayden P Baker
    From the Department of Orthopaedic Surgery, University of Chicago, Chicago, IL.
  • Sarthak Aggarwal
    The University of Chicago Department of Orthopaedic Surgery, Chicago, IL 60637, United States.
  • Senthooran Kalidoss
  • Matthew Hess
    The University of Chicago Department of Orthopaedic Surgery, Chicago, IL 60637, United States.
  • Rex Haydon
    The University of Chicago Department of Orthopaedic Surgery, Chicago, IL 60637, United States.
  • Jason A Strelzow

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