Automated phenotyping of mild cognitive impairment and Alzheimer's disease and related dementias using electronic health records.

Journal: International journal of medical informatics
Published Date:

Abstract

OBJECTIVES: Unstructured and structured data in electronic health records (EHR) are a rich source of information for research and quality improvement studies. However, extracting accurate information from EHR is labor-intensive. Timely and accurate identification of patients with Alzheimer's Disease, related dementias (ADRD), or mild cognitive impairment (MCI) is critical for improving patient outcomes through early intervention, optimizing care plans, and reducing healthcare system burdens. Here we introduce an automated EHR phenotyping model to streamline this process and enable efficient identification of these conditions.

Authors

  • Ruoqi Wei
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
  • Stephanie S Buss
    Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
  • Rebecca Milde
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
  • Marta Fernandes
    IDMEC, Instituto Superior Técnico, Universidade de Lisboa, Portugal. Electronic address: marta.fernandes@tecnico.ulisboa.pt.
  • Daniel Sumsion
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
  • Elijah Davis
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
  • Wan-Yee Kong
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
  • Yiwen Xiong
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
  • Jet Veltink
    Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
  • Samvrit Rao
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
  • Tara M Westover
    Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
  • Lydia Petersen
    Department of Bioengineering, Clemson University, 301 Rhodes Research Center, Clemson, 29634, SC, USA.
  • Niels Turley
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
  • Arjun Singh
    School of Computing and IT, Manipal University Jaipur, Jaipur, Rajasthan, India.
  • Sudeshna Das
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Valdery Moura Junior
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
  • Manohar Ghanta
    Department of Neurology, Massachusetts General Hospital, Boston, MA.
  • Aditya Gupta
    Department of E & TC Engineering, College of Engineering, Pune, India.
  • Jennifer Kim
    Yale School of Medicine, New Haven, CT, United States.
  • Alice D Lam
    Epilepsy Division, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: Lam.Alice@mgh.harvard.edu.
  • Katie L Stone
    California Pacific Medical Center, Research Institute, San Francisco.
  • Emmanuel Mignot
    Center for Sleep Sciences and Medicine, Stanford School of Medicine, Palo Alto, CA, USA.
  • Dennis Hwang
    Southern California Permanente Medical Group, Los Angeles, California.
  • Lynn Marie Trotti
    Emory University, Atlanta, GA, United States.
  • Gari D Clifford
    Department of Biomedical Informatics, Emory University, Atlanta, GA, United States.
  • Umakanth Katwa
    Boston Children's Hospital, Boston, MA, United States.
  • Robert J Thomas
    Division of Pulmonary, Critical Care & Sleep, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
  • Shibani Mukerji
    Department of Neurology, Massachusetts General Hospital, Boston, MA, United States.
  • Sahar F Zafar
    Department of Neurology, Massachusetts General Hospital, Boston, MA.
  • M Brandon Westover
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  • Haoqi Sun
    Neurology Department, Massachusetts General Hospital, Wang 720, Boston, MA, USA.