Statin use and longitudinal bone marrow lesion burden: analysis of knees without osteoarthritis from the Osteoarthritis Initiative study.

Journal: Skeletal radiology
Published Date: Jan 31, 2025

Abstract

OBJECTIVES: Knee subchondral bone marrow lesions (BMLs) are one of the hallmark features of structural osteoarthritis (OA) and are potential targets for statins' disease-modifying effect. We aimed to determine the association between statin use and longitudinal changes in magnetic resonance imaging (MRI)-based BML volume in participants without radiographic knee OA at baseline.

Authors

  • Kamyar Moradi
    From the Russell H. Morgan Department of Radiology and Radiological Science (S.D., J.G.K., E.G., H.A.I., K.M., K.T., E.K.F.) and Department of Biomedical Engineering (W.B.Z.), Johns Hopkins University School of Medicine, 601 N Carolina St, Baltimore, MD 21287; Division of Musculoskeletal Imaging, Department of Radiology, Mayo Clinic, Rochester, Minn (F.I.B.); Department of Radiology, New York University Grossman School of Medicine, New York, NY (J.F.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); and Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, Mass (A.G.).
  • Bahram Mohajer
    From the Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104-4283.
  • Ali Guermazi
    Department of Radiology, Boston University School of Medicine, Boston, MA, 02118, USA.
  • Roham Hadidchi
    Department of Radiology and Radiologic Sciences, Johns Hopkins University, Baltimore, MD, United States.
  • Soheil Mohammadi
    School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: soheil.mhm@gmail.com.
  • Xu Cao
  • Mei Wan
    Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Frank W Roemer
    Department of Radiology, Boston University School of Medicine, Boston, United States; Department of Radiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany. Electronic address: Frank.Roemer@uk-erlangen.de.
  • Shadpour Demehri
    Department of Radiology, The Johns Hopkins Hospital, Baltimore, MD 21287.

Keywords

External Resources

Popular Topics
Recent Journals