Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure.

Journal: Hereditas
Published Date:

Abstract

BACKGROUND: Sepsis is frequently combined with acute liver failure (ALF), a critical determinant in the mortality of septic patients. Pyroptosis is a significant form of programmed cell death that plays an important role in the inflammatory response. Research has been conducted to elucidate the relationship between pyroptosis, sepsis, and ALF, but the mechanism of action remains unclear.

Authors

  • Jing Yan
    Department of Neurology, Shanghai Pudong New Area People's Hospital, Shanghai, China.
  • Yifeng Pan
    The School of Big Data and Artificial Intelligence, Anhui Xinhua University, Hefei, China.
  • Chaoqi Chen
  • Lijian Liu
    Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, People's Republic of China.
  • Jinjing Tan
    The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530001, Guangxi, China.
  • Juan Li
    Department of Hygienic Inspection, School of Public Health, Jilin University 1163 Xinmin Street Changchun 130021 Jilin China songxiuling@jlu.edu.cn li_juan@jlu.edu.cn jinmh@jlu.edu.cn +86 43185619441.
  • Liqun Li
    Department of Plastic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. wz.llq@wmu.edu.cn.
  • Sheng Xie
    Department of Radiology, China-Japan Friendship Hospital, 2 Yinghua Dong Street, Hepingli, Chao Yang District, Beijing, 100029, China. xs_mri@126.com.