Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure.
Journal:
Hereditas
Published Date:
Aug 8, 2025
Abstract
BACKGROUND: Sepsis is frequently combined with acute liver failure (ALF), a critical determinant in the mortality of septic patients. Pyroptosis is a significant form of programmed cell death that plays an important role in the inflammatory response. Research has been conducted to elucidate the relationship between pyroptosis, sepsis, and ALF, but the mechanism of action remains unclear.