Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery.

Journal: PLoS neglected tropical diseases
PMID: 26114876

Abstract

BACKGROUND: Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity.

Authors

  • Sean Ekins
    Collaborations in Chemistry, 5616 Hilltop Needmore Road, Fuquay-Varina, NC 27526, USA; Collaborative Drug Discovery, 1633 Bayshore Highway, Suite 342, Burlingame, CA 94010, USA; Collaborations Pharmaceuticals, Inc., 5616 Hilltop Needmore Road, Fuquay-Varina, NC 27526, USA; Phoenix Nest, Inc., P.O. Box 150057, Brooklyn, NY 11215, USA; Hereditary Neuropathy Foundation, 401 Park Avenue South, 10th Floor, New York, NY 10016, USA. Electronic address: ekinssean@yahoo.com.
  • Jair Lage de Siqueira-Neto
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, United States of America.
  • Laura-Isobel McCall
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, United States of America.
  • Malabika Sarker
    SRI International, Menlo Park, California, United States of America.
  • Maneesh Yadav
    SRI International, Menlo Park, California, United States of America.
  • Elizabeth L Ponder
    Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford, California, United States of America.
  • E Adam Kallel
    Collaborative Drug Discovery, Burlingame, California, United States of America.
  • Danielle Kellar
    Department of Pathology, University of California, San Francisco, San Francisco, California, United States of America.
  • Steven Chen
    Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America.
  • Michelle Arkin
    Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America.
  • Barry A Bunin
    Collaborative Drug Discovery, Burlingame, California, United States of America.
  • James H McKerrow
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, California, United States of America.
  • Carolyn Talcott
    SRI International, Menlo Park, California, United States of America.

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