African journal of traditional, complementary, and alternative medicines : AJTCAM
28852732
BACKGROUND: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present stud...
BACKGROUND: Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity.
A new family of imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxide with antiproliferative Trypanosoma cruzi properties was identified from a neural network model published by our group. The synthesis and evaluation of this new class of trypanocidal agents ...
International journal of molecular sciences
31181717
Small-molecule compounds that have promising activity against macromolecular targets from occasionally fail when tested in whole-cell phenotypic assays. This outcome can be attributed to many factors, including inadequate physicochemical and pharmac...
Species Distribution Modelling (SDM) determines habitat suitability of a species across geographic areas using macro-climatic variables; however, micro-habitats can buffer or exacerbate the influence of macro-climatic variables, requiring links betwe...
The 158 bug species that make up the subfamily Triatominae are the potential vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. Despite recent progress in developing a picture-based automated system for identification of triatomin...
Chagas disease (CD), caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), represents a major public health concern in most of the American continent and causes 12,000 deaths every year. CD clinically manifests in two phases (acute and chron...