AIMC Topic: Genome, Protozoan

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Machine learning methods for predicting essential metabolic genes from Plasmodium falciparum genome-scale metabolic network.

PloS one Dec 23, 2024
Essential genes are those whose presence is vital for a cell's survival and growth. Detecting these genes in disease-causing organisms is critical for various biological studies, including understanding microbe metabolism, engineering genetically mod...
Genes, Essential Computational Biology Genome, Protozoan Machine Learning Plasmodium falciparum Metabolic Networks and Pathways
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IFPTML Mapping of Drug Graphs with Protein and Chromosome Structural Networks vs. Pre-Clinical Assay Information for Discovery of Antimalarial Compounds.

International journal of molecular sciences Dec 2, 2021
The parasite species of genus causes Malaria, which remains a major global health problem due to parasite resistance to available Antimalarial drugs and increasing treatment costs. Consequently, computational prediction of new Antimalarial compounds...
Genome, Protozoan Reproducibility of Results Drug Evaluation, Preclinical Plasmodium falciparum Algorithms Protozoan Proteins Databases, Pharmaceutical Models, Theoretical Machine Learning Markov Chains Drug Discovery Antimalarials
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Using deep learning to identify recent positive selection in malaria parasite sequence data.

Malaria journal Jun 14, 2021
BACKGROUND: Malaria, caused by Plasmodium parasites, is a major global public health problem. To assist an understanding of malaria pathogenesis, including drug resistance, there is a need for the timely detection of underlying genetic mutations and ...
Deep Learning Genome, Protozoan Selection, Genetic Plasmodium falciparum Sequence Analysis, DNA Genome Size Plasmodium vivax
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Symbiont modulates expression of specific gene categories in Angomonas deanei.

Memorias do Instituto Oswaldo Cruz Oct 3, 2016
Trypanosomatids are parasites that cause disease in humans, animals, and plants. Most are non-pathogenic and some harbor a symbiotic bacterium. Endosymbiosis is part of the evolutionary process of vital cell functions such as respiration and photosyn...
Trypanosomatina Genes, Protozoan Gene Ontology Gene Expression Regulation Symbiosis RNA, Protozoan Bacteria Genome, Protozoan Animals Genomics Humans Gene Expression Profiling Transcriptome
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Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery.

PLoS neglected tropical diseases Jun 26, 2015
BACKGROUND: Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity.
Genome, Protozoan Metabolic Networks and Pathways High-Throughput Screening Assays Machine Learning Bayes Theorem Mice Female Mice, Inbred BALB C Humans Computational Biology Cell Line Disease Models, Animal Chagas Disease Trypanosoma cruzi Trypanocidal Agents Drug Discovery Animals
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